- 专利标题: Pyrazole derivatives
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申请号: US10118512申请日: 2002-04-05
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公开(公告)号: US07109228B2公开(公告)日: 2006-09-19
- 发明人: Lyn Howard Jones , Charles Eric Mowbray , David Anthony Price , Matthew Duncan Selby , Paul Anthony Stupple
- 申请人: Lyn Howard Jones , Charles Eric Mowbray , David Anthony Price , Matthew Duncan Selby , Paul Anthony Stupple
- 申请人地址: US CA La Jolla
- 专利权人: Agouron Pharmaceuticals, Inc.
- 当前专利权人: Agouron Pharmaceuticals, Inc.
- 当前专利权人地址: US CA La Jolla
- 代理商 Keith D. Hutchinson; Bryan C. Zielinski; Peter C. Richardson
- 优先权: GB0108999.4 20010410; GB0127426.5 20011115
- 主分类号: A61K31/415
- IPC分类号: A61K31/415 ; C07D231/18
摘要:
This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivatives thereof, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such, the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).
公开/授权文献
- US20030100554A1 Pyrazole derivatives 公开/授权日:2003-05-29