Invention Grant
- Patent Title: Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
- Patent Title (中): 噻吩脒，其组合物和治疗补体介导的疾病和病症的方法
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Application No.: US10445817Application Date: 2003-05-28
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Publication No.: US07109354B2Publication Date: 2006-09-19
- Inventor: Nalin Subasinghe , Ehab Khalil , Kristi Leonard , Farah Ali , Heather Rae Hufnagel , Jeremy M. Travins , Shelley K. Ballentine , Kenneth T. Wilson , Maxwell D. Cummings , Wenxi Pan , Joan Gushue , Sanath Meegalla , Mark Wall , Jinsheng Chen , M. Jonathan Rudolph , Hui Huang
- Applicant: Nalin Subasinghe , Ehab Khalil , Kristi Leonard , Farah Ali , Heather Rae Hufnagel , Jeremy M. Travins , Shelley K. Ballentine , Kenneth T. Wilson , Maxwell D. Cummings , Wenxi Pan , Joan Gushue , Sanath Meegalla , Mark Wall , Jinsheng Chen , M. Jonathan Rudolph , Hui Huang
- Applicant Address: US PA Yardley
- Assignee: 3-Dimensional Pharmaceuticals, Inc.
- Current Assignee: 3-Dimensional Pharmaceuticals, Inc.
- Current Assignee Address: US PA Yardley
- Main IPC: C07D333/02
- IPC: C07D333/02 ; C07D333/32
Abstract:
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.
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