发明授权
- 专利标题: T cell epitopes of ryegrass pollen allergen
- 专利标题(中): 黑麦草花粉过敏原的T细胞表位
-
申请号: US08737904申请日: 1994-08-05
-
公开(公告)号: US07112333B1公开(公告)日: 2006-09-26
- 发明人: Irwin J. Griffith , Mei-Chang Kuo , Mohammad Luqman
- 申请人: Irwin J. Griffith , Mei-Chang Kuo , Mohammad Luqman
- 申请人地址: US CO Loveland
- 专利权人: Heska Corporation
- 当前专利权人: Heska Corporation
- 当前专利权人地址: US CO Loveland
- 代理机构: Lahive & Cockfield, LLP
- 国际申请: PCT/US94/09024 WO 19940805
- 国际公布: WO95/06728 WO 19950309
- 主分类号: A61K38/04
- IPC分类号: A61K38/04 ; A61K38/10 ; C07K7/00 ; C07K7/06
摘要:
The present invention provides isolated peptides of Lol p V, a major protein allergen of the species Lolium perenne. Therapeutic peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen of Lol p V. Diagnostic peptides within the scope of the invention bind IgE. The invention also provides modified peptides having similar or enhanced therapeutic properties or other desirable properties as the corresponding, naturally-occurring allergen or portion thereof. The invention further provides nucleic acid sequences coding for peptides of the invention. Use of the therapeutic compositions comprising one or more peptides of the invention in the manufacture of medicaments for treating sensitivity to Lol p V or an allergen immunologically related to Lol p V, or for general ryegrass sensitivity in an individual, is also provided. The invention also provides nucleic acid sequence coding for Dac g V protein allergen as well as the amino acid sequence of Dac g V protein allergen.