发明授权
- 专利标题： Methods for treatment of tumors and metastases using a combination of anti-angiogenic and immuno therapies
- 专利标题（中）： 使用抗血管生成和免疫疗法的组合治疗肿瘤和转移的方法
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申请号： US09502732申请日： 2000-02-11
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公开(公告)号： US07115261B1公开(公告)日： 2006-10-03
- 发明人: Holger N. Lode , Ralph A. Reisfeld , David A. Cheresh , Stephen D. Gillies
- 申请人： Holger N. Lode , Ralph A. Reisfeld , David A. Cheresh , Stephen D. Gillies
- 申请人地址： US CA La Jolia US MA Billerica
- 专利权人： The Scripps Research Institute,EMD Lexigen Research Center Corp.
- 当前专利权人： The Scripps Research Institute,EMD Lexigen Research Center Corp.
- 当前专利权人地址： US CA La Jolia US MA Billerica
- 代理机构： Olson & Hierl, Ltd.
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K39/395 ; A61K38/19
摘要：
The invention teaches methods for treating tumors and tumor metastases in a mammal comprising administering, to a mammal in need of treatment, a therapeutic amount of an antagonist sufficient to inhibit angiogenesis in combination with a therapeutic amount of anti-tumor immunotherapeutic agent, such as a anti-tumor antigen antibody/cytokine fusion protein having a cytokine and a recombinant immunoglobulin polypeptide chain sufficient to elicit a cytokine-specific biological response.
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