发明授权
- 专利标题: Anti-TRAIL-R antibodies
- 专利标题(中): 抗TRAIL-R抗体
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申请号: US10478056申请日: 2002-05-17
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公开(公告)号: US07115717B2公开(公告)日: 2006-10-03
- 发明人: Eiji Mori , Shiro Kataoka
- 申请人: Eiji Mori , Shiro Kataoka
- 申请人地址: JP Tokyo
- 专利权人: Kirin Beer Kabushiki Kaisha
- 当前专利权人: Kirin Beer Kabushiki Kaisha
- 当前专利权人地址: JP Tokyo
- 代理机构: Foley & Lardner LLP
- 优先权: JP2001-150213 20010518; JP2001-243040 20010809; JP2001-314489 20011011
- 国际申请: PCT/JP02/04816 WO 20020517
- 国际公布: WO02/094880 WO 20021128
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/30
摘要:
Anti-TRAIL-R1 and R2 antibodies or functional fragments thereof, having at least one property selected from the following (a) to (c) of:(a) having activity to induce apoptosis in carcinoma cells expressing TRAIL-R1 and/or TRAIL-R2;(b) not having effect on normal human cells expressing TRAIL-R1 and/or TRAIL-R2; and(c) not inducing human hepatocyte toxicity.
公开/授权文献
- US20040214235A1 Anti-trail-r antibodies 公开/授权日:2004-10-28
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