A method of making screen printing frames can include, in certain illustrative embodiments, affixing at least two frames to one another, applying a masking film to both frames, exposing the frames, removing the unhardened emulsion in the meshes, and separating the frames from one another for deployment in a screen printing apparatus. This exemplary process can be used to create images in substantially complete registration with one another on frames having different mesh counts. Stated another way, these embodiments permit the use of multiple frames to print different inks through different meshes in a single pass to form images in substantially complete registration with one another. In certain preferred embodiments, a screen printing apparatus can include two frames, each having a mesh with a different pitch, wherein the frames are adapted to receive different inks and held in fixed register during a screen printing operation.