发明授权
US07118730B2 Quinoline derivative as diagnostic probe for disease with tau protein accumulation
失效
喹啉衍生物作为具有tau蛋白积聚的疾病的诊断探针
- 专利标题： Quinoline derivative as diagnostic probe for disease with tau protein accumulation
- 专利标题（中）： 喹啉衍生物作为具有tau蛋白积聚的疾病的诊断探针
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申请号： US10494314申请日： 2003-11-28
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公开(公告)号： US07118730B2公开(公告)日： 2006-10-10
- 发明人: Yukitsuka Kudo , Masako Suzuki , Takahiro Suemoto , Nobuyuki Okamura , Tsuyoshi Shiomitsu , Hiroshi Shimazu
- 申请人： Yukitsuka Kudo , Masako Suzuki , Takahiro Suemoto , Nobuyuki Okamura , Tsuyoshi Shiomitsu , Hiroshi Shimazu
- 申请人地址： JP Osaka
- 专利权人： BF Research Institute, Inc.
- 当前专利权人： BF Research Institute, Inc.
- 当前专利权人地址： JP Osaka
- 代理机构： Nixon Peabody LLP
- 代理商 Donald R. Studebaker
- 优先权： JP2002-363369 20021216
- 国际申请： PCT/JP03/15269 WO 20031128
- 国际公布： WO2004/054978 WO 20040701
- 主分类号： A61K49/00
- IPC分类号： A61K49/00
摘要：
The present invention provides compounds, or salts or solvates thereof, which can be used as probes for the imaging diagnosis of diseases in which tau protein accumulates, and compositions and kits comprising such compounds, or salts or solvates thereof. The present invention also provides a method for staining neurofibrillary tangles in brain samples, and a pharmaceutical composition for the treatment and/or prophylaxis of a disease in which β-sheet structure is the cause or possible cause.
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