发明授权
US07119081B2 Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
有权
雌激素-17-磺酰胺酸盐作为类固醇硫酸酯酶的抑制剂
- 专利标题: Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
- 专利标题(中): 雌激素-17-磺酰胺酸盐作为类固醇硫酸酯酶的抑制剂
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申请号: US10367114申请日: 2003-02-14
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公开(公告)号: US07119081B2公开(公告)日: 2006-10-10
- 发明人: Barry Victor Lloyd Potter , Michael John Reed , Bertrand Leblond , Matthew Paul Leese , Atul Purohit
- 申请人: Barry Victor Lloyd Potter , Michael John Reed , Bertrand Leblond , Matthew Paul Leese , Atul Purohit
- 申请人地址: GB Berkshire
- 专利权人: Sterix Limited
- 当前专利权人: Sterix Limited
- 当前专利权人地址: GB Berkshire
- 代理机构: Frommer Lawrence & Haug LLP
- 代理商 Thomas J. Kowalski; Angela M. Collison
- 优先权: GB0020498.2 20000818
- 主分类号: A01N1/00
- IPC分类号: A01N1/00 ; A61K31/56 ; C07J1/00
摘要:
There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R1 and R2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth. There is also provided a compound of Formula VIII wherein R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.
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