- 专利标题： Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
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申请号： US10840478申请日： 2004-05-06
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公开(公告)号： US07125672B2公开(公告)日： 2006-10-24
- 发明人: Stephen K. Picataggio , Quinn Qun Zhu
- 申请人： Stephen K. Picataggio , Quinn Qun Zhu
- 申请人地址： US DE Wilmington
- 专利权人： E. I. du Pont de Nemours and Company
- 当前专利权人： E. I. du Pont de Nemours and Company
- 当前专利权人地址： US DE Wilmington
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N1/19 ; C07H21/04 ; C12N15/63
摘要：
The present invention relates to fatty acid desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to γ-linolenic acid (GLA); α-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-γ-linoleic acid (DGLA); STA to eicosatetraenoic acid (ETA); DGLA to ETA; eicosapentaenoic acid (EPA) to docosapentaenoic acid (DPA); and arachidonic acid (ARA) to EPA. Nucleic acid sequences encoding codon-optimized desaturases and elongases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the codon-optimized desaturase or elongases, and recombinant host microorganisms expressing increased levels of desaturase or elongase are described.
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