发明授权
US07126001B2 Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
有权
细胞分化剂和组蛋白脱乙酰酶抑制剂的类别及其使用方法
- 专利标题： Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof
- 专利标题（中）： 细胞分化剂和组蛋白脱乙酰酶抑制剂的类别及其使用方法
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申请号： US10281875申请日： 2002-10-25
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公开(公告)号： US07126001B2公开(公告)日： 2006-10-24
- 发明人: Ronald Breslow , Sandro Belvedere , Leland Gershell , Thomas A. Miller , Paul A. Marks , Victoria M. Richon , Richard A. Rifkind
- 申请人： Ronald Breslow , Sandro Belvedere , Leland Gershell , Thomas A. Miller , Paul A. Marks , Victoria M. Richon , Richard A. Rifkind
- 申请人地址： US NY New York US NY New York
- 专利权人： Sloan-Kettering Institute for Cancer Research,The Trustees of Columbia University in the City of New York
- 当前专利权人： Sloan-Kettering Institute for Cancer Research,The Trustees of Columbia University in the City of New York
- 当前专利权人地址： US NY New York US NY New York
- 代理机构： Mintz Levin Cohn Ferris Glovsky and Popeo PC
- 代理商 Ivor R. Elrifi, Esq.
- 主分类号： C07D215/38
- IPC分类号： C07D215/38 ; C07D473/02 ; C07C259/04 ; A61K31/47
摘要：
The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkyloxy, or pyridine group; wherein A is an amido moiety, —O—, —S—, —NH—, or —CH2—; and wherein n is an integer from 3 to 8. The present invention also provides a method of selectively inducing growth arrest, terminal differentiation and/or apoptosis of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.
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