Invention Grant
US07129072B1 Crystal of fibroblast growth factor receptor 1 in complex with fibroblast growth factor
有权
成纤维细胞生长因子受体1与成纤维细胞生长因子复合的结晶
- Patent Title: Crystal of fibroblast growth factor receptor 1 in complex with fibroblast growth factor
- Patent Title (中): 成纤维细胞生长因子受体1与成纤维细胞生长因子复合的结晶
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Application No.: US10049429Application Date: 2000-08-30
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Publication No.: US07129072B1Publication Date: 2006-10-31
- Inventor: Joseph Schlessinger , Stevan R. Hubbard , Moosa Mohammadi , Alexander Plotnikov , Zhongtao Zhang , Xiang-Peng Kong
- Applicant: Joseph Schlessinger , Stevan R. Hubbard , Moosa Mohammadi , Alexander Plotnikov , Zhongtao Zhang , Xiang-Peng Kong
- Applicant Address: US NY New York
- Assignee: New York University
- Current Assignee: New York University
- Current Assignee Address: US NY New York
- Agency: Foley & Lardner
- International Application: PCT/US00/23744 WO 20000830
- International Announcement: WO01/16181 WO 20010308
- Main IPC: C12N9/12
- IPC: C12N9/12
Abstract:
The determination and use of three dimensional structures of receptor protein tyrosine kinases and/or their ligands are described. One particular group of such structures includes three dimensional structures of the extracellular domain of RPTKs. The three dimensional structures of RPTKs can faciliate the design and identification of modulators of RPTK function. Other such structures can include of RPTK ligands, such as stem cell factor or a fragment thereof. Modulators of RPTK function can be used to treat diseases that are mediated by inappropriate RPTK activity.
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