发明授权
- 专利标题: Process for the preparation of 4-methyl-7-aminoquinolones
- 专利标题(中): 制备4-甲基-7-氨基喹诺酮的方法
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申请号: US10498456申请日: 2002-12-03
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公开(公告)号: US07144993B2公开(公告)日: 2006-12-05
- 发明人: Johannes Benkhoff , Bernd Lamatsch
- 申请人: Johannes Benkhoff , Bernd Lamatsch
- 申请人地址: US NY Tarrytown
- 专利权人: Ciba Specialty Chemicals Corp.
- 当前专利权人: Ciba Specialty Chemicals Corp.
- 当前专利权人地址: US NY Tarrytown
- 代理商 Tyler A. Stevenson
- 优先权: EP01811206 20011211
- 国际申请: PCT/EP02/13663 WO 20021203
- 国际公布: WO03/050089 WO 20030619
- 主分类号: C07D215/38
- IPC分类号: C07D215/38 ; C07C235/80
摘要:
The present invention relates to a process for the preparation of a compound of the general formula (I), which comprises converting a compound of the general formula (II), in an aprotic organic solvent in the presence of a catalytically active amount of a strong acid (catalyst) or of an agent that liberates a strong acid or of an ammonium salt of a strong acid, it also being possible for the catalyst to be part of the starting material/product, into a compound of formula I, wherein R5, R6 and R8 are each independently of the others a hydrogen atom, a nitro group, a sulfo group, a halogen atom, a pseudohalogen, a group COOR1 or CONHR2 or a C1-8 alkyl, C1-8 alkoxy or aryloxy radical, an amide group, a thioalkyl or thioaryl radical, an alkyl- or aryl-sulfonyl radical, an alkyl- or aryl-sulfinyl radical, a trifluoromethyl group or a phosphono group, R1 and R2 being a hydrogen atom or a C1-8 alkyl radical or an aryl or aralkyl radical, R10 is a group —C(O)CH2C(O)CH3 and R11 is a hydrogen atom or an acyl radical, or R10 and R11 are a group —C(O)CH2C(O)CH3. The process according to the invention is simple to perform and results in products of high chemical purity and high isomeric purity in a high yield
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