发明授权
- 专利标题： Indole compounds, process for producing the same and drugs containing the same as the active ingredient
- 专利标题（中）： 吲哚化合物，其制备方法和含有与活性成分相同的药物
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申请号： US10488834申请日： 2002-09-06
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公开(公告)号： US07153852B2公开(公告)日： 2006-12-26
- 发明人: Kazuhiko Torisu , Tomoyuki Hasegawa , Kaoru Kobayashi , Fumio Nambu
- 申请人： Kazuhiko Torisu , Tomoyuki Hasegawa , Kaoru Kobayashi , Fumio Nambu
- 申请人地址： JP Osaka
- 专利权人： Ono Pharmaceutical Co., Ltd.
- 当前专利权人： Ono Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Osaka
- 代理机构： Sughrue Mion, PLLC
- 优先权： JP2001-271281 20010907
- 国际申请： PCT/JP02/09077 WO 20020906
- 国际公布： WO03/022813 WO 20030320
- 主分类号： A61K31/538
- IPC分类号： A61K31/538 ; A61K31/404 ; C07D265/36 ; C07D209/08
摘要：
Indole derivatives represented by formula (I) wherein all symbols represent the same as that in specification), production methods thereof, and DP receptor antagonist comprising them as active ingredients.Since the compounds of formula (I) binds and antagonizes to DP receptor, they are useful for the prevention and/or treatment against allergic diseases, diseases accompanied with itching, secondary diseases generated by behaviors caused by itching, inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, cerebrovascular disorder, pleuritis complicated by rheumatoid arthritis, ulcerative colitis.
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