发明授权
- 专利标题： αv integrin receptor antagonists
- 专利标题（中）： alphav整合素受体拮抗剂
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申请号： US10618414申请日： 2003-07-10
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公开(公告)号： US07153862B2公开(公告)日： 2006-12-26
- 发明人: Ben C. Askew , Michael J. Breslin , Mark E. Duggan , John H. Hutchinson , Robert S. Meissner , James J. Perkins , Thomas G. Steele , Michael A. Patane
- 申请人： Ben C. Askew , Michael J. Breslin , Mark E. Duggan , John H. Hutchinson , Robert S. Meissner , James J. Perkins , Thomas G. Steele , Michael A. Patane
- 申请人地址： US NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 Patricia A. Shatynski; Mark R. Daniel
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; A61K31/505 ; C07D471/02 ; C07D265/36 ; C07D498/02
摘要：
The present invention relates to novel alkanoic acid derivatives thereof, their synthesis, and their use as αv integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3 and/or αvβ5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth.
公开/授权文献
- US20040019037A1 Alpha V integrin receptor antagonists 公开/授权日：2004-01-29
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