Invention Grant
US07153876B2 Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and their use 有权
丙二酰胺和丙二酸酯衍生物具有抗血栓活性,其制备及其用途

Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and their use
Abstract:
Compounds of formula I, in which R1, R2, A, and B having the definitions set forth in the claims, are valuable pharmacologically active compounds, which exhibit a strong antithrombotic effect and are suitable, for example, for treating thromboembolic diseases and restenoses. They are reversible inhibitors of the blood clotting enzyme factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. Also disclosed are processes for the preparation of compounds of formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
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