Invention Grant
US07153876B2 Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and their use
有权
丙二酰胺和丙二酸酯衍生物具有抗血栓活性,其制备及其用途
- Patent Title: Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and their use
- Patent Title (中): 丙二酰胺和丙二酸酯衍生物具有抗血栓活性,其制备及其用途
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Application No.: US10634827Application Date: 2003-08-06
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Publication No.: US07153876B2Publication Date: 2006-12-26
- Inventor: Manfred Schudok , Otmar Klingler , Hans-Peter Nestler , Hans Matter , Herman Schreuder
- Applicant: Manfred Schudok , Otmar Klingler , Hans-Peter Nestler , Hans Matter , Herman Schreuder
- Applicant Address: DE Frankfurt am Main
- Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee Address: DE Frankfurt am Main
- Agent Ronald G. Ort
- Priority: EP00121551 20000930
- Main IPC: C07D213/75
- IPC: C07D213/75 ; A61K31/44 ; A61P7/02 ; A61P9/10

Abstract:
Compounds of formula I, in which R1, R2, A, and B having the definitions set forth in the claims, are valuable pharmacologically active compounds, which exhibit a strong antithrombotic effect and are suitable, for example, for treating thromboembolic diseases and restenoses. They are reversible inhibitors of the blood clotting enzyme factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. Also disclosed are processes for the preparation of compounds of formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
Public/Granted literature
- US20040034027A1 Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and their use Public/Granted day:2004-02-19
Information query
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