发明授权
- 专利标题: Vla-4 inhibitors
- 专利标题(中): Vla-4抑制剂
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申请号: US10451159申请日: 2001-12-28
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公开(公告)号: US07157487B2公开(公告)日: 2007-01-02
- 发明人: Atsushi Nakayama , Nobuo Machinaga , Yoshiyuki Yoneda , Yuichi Sugimoto , Jun Chiba , Toshiyuki Watanabe , Shin Iimura
- 申请人: Atsushi Nakayama , Nobuo Machinaga , Yoshiyuki Yoneda , Yuichi Sugimoto , Jun Chiba , Toshiyuki Watanabe , Shin Iimura
- 申请人地址: JP Tokyo
- 专利权人: Daiichi Pharmaceutical Co., Ltd.
- 当前专利权人: Daiichi Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Tokyo
- 代理机构: Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
- 优先权: JP2000-402890 20001228; JP2001-149923 20010518
- 国际申请: PCT/JP01/11641 WO 20011228
- 国际公布: WO02/053534 WO 20020711
- 主分类号: A61K31/405
- IPC分类号: A61K31/405 ; C07D209/04
摘要:
The present invention relates to a compound represented by the following formula (I): (wherein, W represents WA-A1-WB- (in which, WA is substituted or unsubstituted aryl, etc., A1 is —NR1—, single bond, —C(O)—, etc., and WB is substituted or unsubstituted arylene, etc.), R is single bond, —NH—, —OCH2—, alkenylene, etc., X is —C(O)—, —CH2—, etc., and M is, for example, the following formula: (in which, R11, R12 and R13 each independently represents hydrogen, hydroxyl, amino, halogen, etc., R14 is hydrogen or lower alkyl, Y represents —CH2—O—, etc., Z is substituted or unsubstituted arylene, etc., A2 is single bond, etc, and R10 is hydroxyl or lower alkoxy)), or salt thereof; and a medicament containing the same. This compound or salt thereof selectively inhibits binding of cell adhesion molecules to VLA-4 and exhibits high bioavailability so that it is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like.
公开/授权文献
- US20040110945A1 Vla-4 inhibitors 公开/授权日:2004-06-10