Invention Grant
- Patent Title: Processes for preparation of cyclopropylethanol, cyclopropylacetonitorile and intermediates of both
- Patent Title (中): 制备环丙基乙醇，环丙基乙腈和中间体的方法
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Application No.: US10493224Application Date: 2002-10-31
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Publication No.: US07164047B2Publication Date: 2007-01-16
- Inventor: Katsuji Ujita
- Applicant: Katsuji Ujita
- Applicant Address: JP Kurashiki
- Assignee: Kuraray Co., Ltd.
- Current Assignee: Kuraray Co., Ltd.
- Current Assignee Address: JP Kurashiki
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
- Priority: JP2001-345555 20011112; JP2002-029169 20020206
- International Application: PCT/JP02/11345 WO 20021031
- International Announcement: WO03/042145 WO 20030522
- Main IPC: C07C29/14
- IPC: C07C29/14 ; C07C253/30 ; C07C249/08 ; C07C255/31
Abstract:
A process for preparation of cyclopropylethanol, which comprises subjecting a 3-cyclopropyl-2,3-epoxypropionic acid ester to solvolysis, treating the product of the solvolysis with an acid to obtain cyclopropylacetaldehyde, and reducing the obtained cyclopropylacetaldehyde; and a process for preparation of cyclopropylacetonitrile, which comprises subjecting a 3-cyclopropyl-2,3-epoxypropionic acid ester to solvolysis in the presence of a base, treating the product of the solvolysis with an acid to obtain cyclopropylacetaldehyde, reacting the obtained cyclopropylacetaldehyde with hydroxylamine or salts thereof to obtain cyclopropaneacetaldehyde oxime, and reacting the obtained cyclopropaneacetaldehyde oxime with acetic anhydride. According to the present invention, cyclopropylethanol and cyclopropylacetonitrile can be prepared at low costs and industrially advantageously.
Public/Granted literature
- US20050020846A1 Processes for preparation of cyclopropylethanol, cyclo-propylacetonitrile and intermediates of both Public/Granted day:2005-01-27
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