发明授权
- 专利标题: Degradable heterobifunctional poly(ethylene glycol) acrylates
- 专利标题(中): 可降解异双功能聚(乙二醇)丙烯酸酯
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申请号: US10684946申请日: 2003-10-14
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公开(公告)号: US07166304B2公开(公告)日: 2007-01-23
- 发明人: J. Milton Harris , Xuan Zhao
- 申请人: J. Milton Harris , Xuan Zhao
- 申请人地址: CH Martigny
- 专利权人: Debio Recherche Pharmaceutique S.A.
- 当前专利权人: Debio Recherche Pharmaceutique S.A.
- 当前专利权人地址: CH Martigny
- 代理机构: Alston & Bird LLP
- 主分类号: A61K9/00
- IPC分类号: A61K9/00 ; A61K47/48 ; C12N11/00 ; G01N33/543 ; C07K17/00
摘要:
A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coupling to a target. Hydrogels can be prepared. The hydrogels can be used as a carrier for a protein or a pharmaceutical agent that can be readily released in a controlled fashion.
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