发明授权
US07166722B2 N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-n′-(5-methyl-3-isoxazolyl)urea salt in crystalline form
有权
N- {2-氯-4 - [（6,7-二甲氧基-4-喹啉基）氧基]苯基} -N' - （5-甲基-3-异恶唑基）脲盐
![N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-n′-(5-methyl-3-isoxazolyl)urea salt in crystalline form](/docs/US/2007-01-23/US07166722B2/abs.jpg.600x600.jpg)
- 专利标题： N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-n′-(5-methyl-3-isoxazolyl)urea salt in crystalline form
- 专利标题（中）： N- {2-氯-4 - [（6,7-二甲氧基-4-喹啉基）氧基]苯基} -N' - （5-甲基-3-异恶唑基）脲盐
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申请号： US10532104申请日： 2003-10-21
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公开(公告)号： US07166722B2公开(公告)日： 2007-01-23
- 发明人: Naoki Matsunaga , Satoshi Yoshida , Ayako Yoshino , Tatsuo Nakajima
- 申请人： Naoki Matsunaga , Satoshi Yoshida , Ayako Yoshino , Tatsuo Nakajima
- 申请人地址： JP Tokyo-To
- 专利权人： Kirin Beer Kabushiki Kaisha
- 当前专利权人： Kirin Beer Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo-To
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
- 优先权： JP2002-306101 20021021
- 国际申请： PCT/JP03/13439 WO 20031021
- 国际公布： WO2004/035572 WO 20040429
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D401/14
![N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-n′-(5-methyl-3-isoxazolyl)urea salt in crystalline form](/abs-image/US/2007/01/23/US07166722B2/abs.jpg.150x150.jpg)
摘要：
The present invention provides a crystal of a pharmaceutically acceptable salt of N-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(5-methyl-3-isoxazolyl) urea. This crystal of salt is usable for the therapy of a disease selected from the group consisting of tumors, diabetic retinopathy, chronic rheumatism, psoriasis, atherosclerosis, Kaposi's sarcoma, and exudation type age-related maculopathy, and has characteristics suitable for applications of oral pharmaceutical preparations.
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