- 专利标题： Medical devices employing triazine compounds and compositions thereof
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申请号： US10951316申请日： 2004-09-27
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公开(公告)号： US07169784B2公开(公告)日： 2007-01-30
- 发明人: Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalger Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Bhatlapenumarthy Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
- 申请人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalger Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Bhatlapenumarthy Sesha Sridevi Alluri , Potlapally Rajender Kumar , Gaddam Om Reddy
- 申请人地址： US GA Norcross
- 专利权人： Reddy US Therapeutics, Inc.
- 当前专利权人： Reddy US Therapeutics, Inc.
- 当前专利权人地址： US GA Norcross
- 代理商 Milagros A. Cepeda; Edward D. Pergament; Robert A. Franks
- 主分类号： A61M31/00
- IPC分类号： A61M31/00 ; A61M2/86 ; C07D251/70 ; C07D251/52 ; C07D251/30
摘要：
The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
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