发明授权
US07169819B2 Pharmaceutical compositions of fenretinide having increased bioavailability and methods of using the same
有权
具有增加的生物利用度的芬维A胺的药物组合物及其使用方法
- 专利标题： Pharmaceutical compositions of fenretinide having increased bioavailability and methods of using the same
- 专利标题（中）： 具有增加的生物利用度的芬维A胺的药物组合物及其使用方法
-
申请号： US10010914申请日： 2001-12-05
-
公开(公告)号： US07169819B2公开(公告)日： 2007-01-30
- 发明人: Shanker Gupta , Barry J. Maurer , C. Patrick Reynolds , B. Rao Vishnuvajjala
- 申请人： Shanker Gupta , Barry J. Maurer , C. Patrick Reynolds , B. Rao Vishnuvajjala
- 申请人地址： US CA Los Angeles
- 专利权人： Childrens Hospital Los Angeles
- 当前专利权人： Childrens Hospital Los Angeles
- 当前专利权人地址： US CA Los Angeles
- 代理机构： Myers Bigel Sibley & Sajovec P.A.
- 主分类号： A61K31/07
- IPC分类号： A61K31/07 ; A61K47/00 ; A61P35/00
摘要：
A pharmaceutical composition for parenteral delivery, comprising a retinide such as fenretinide in combination with a solvent capable of dispersing or solubilizing the retinide. The solvent comprises an alcohol, such as ethanol, in combination with an alkoxylated castor oil, such as CREMOPHOR® EL, or comprising a retinide, such as fenretinide, in an emulsion composed of a lipoid dispersed in an aqueous phase, a stabilizing amount of a non-ionic surfactant, optionally a solvent, and optionally an isotonic agent. In addition, a method of use in the treatment of hyperproliferative disorders, such as cancers is described.
公开/授权文献
信息查询
