发明授权
- 专利标题: Method and preparations for stabilizing biological materials by drying methods without freezing
- 专利标题(中): 通过干燥方法稳定生物材料而不冻结的方法和制剂
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申请号: US09051918申请日: 1996-10-24
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公开(公告)号: US07172999B2公开(公告)日: 2007-02-06
- 发明人: Markus Mattern , Gerhard Winter
- 申请人: Markus Mattern , Gerhard Winter
- 申请人地址: DE Mannheim
- 专利权人: Roche Diagnostics GmbH
- 当前专利权人: Roche Diagnostics GmbH
- 当前专利权人地址: DE Mannheim
- 代理机构: Rothwell, Figg, Ernst & Manbeck pc
- 优先权: DE19539574 19951025
- 国际申请: PCT/EP96/04627 WO 19961024
- 国际公布: WO97/15288 WO 19970501
- 主分类号: A61K38/18
- IPC分类号: A61K38/18 ; C07K14/505
摘要:
The present invention concerns processes for the production of dry, partially amorphous products containing biologically active and in particular therapeutically active material which are macroscopically homogeneous substance mixtures, the substance mixtures being selected from at least one substance of each of the groups (i) carbohydrate or zwitterion with a polar residue and derivatives thereof, and (ii) zwitterion with an apolar residue and derivatives thereof, wherein a solution is prepared of the biologically or therapeutically active material and of substances (i) and (ii) and the solution is dried at a product temperature above the freezing point of the solution. In addition the invention concerns new substance mixtures which are obtained by the said process as well as the use thereof in diagnostic or therapeutic methods.