发明授权
- 专利标题: Amine compounds and use thereof
- 专利标题(中): 胺化合物及其用途
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申请号: US10516158申请日: 2003-09-05
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公开(公告)号: US07176227B2公开(公告)日: 2007-02-13
- 发明人: Toru Yamazaki , Shigeyuki Kikumoto , Masahiro Ono , Atsushi Saitou , Haruka Takahashi , Sei Kumakura , Kunitaka Hirose , Mikiro Yanaka , Yoshiyuki Takemura , Shigeru Suzuki , Ryo Matsui
- 申请人: Toru Yamazaki , Shigeyuki Kikumoto , Masahiro Ono , Atsushi Saitou , Haruka Takahashi , Sei Kumakura , Kunitaka Hirose , Mikiro Yanaka , Yoshiyuki Takemura , Shigeru Suzuki , Ryo Matsui
- 申请人地址: JP Tokyo
- 专利权人: Kureha Corporation
- 当前专利权人: Kureha Corporation
- 当前专利权人地址: JP Tokyo
- 代理机构: Hollander Law Firm, P.L.C.
- 优先权: JP2002-265247 20020911
- 国际申请: PCT/JP03/11381 WO 20030905
- 国际公布: WO2004/024697 WO 20040325
- 主分类号: C07D403/12
- IPC分类号: C07D403/12 ; A61K314/178
摘要:
Novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism, and cancer metastasis include compounds represented by the following general formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof: wherein each of n1, n2, and n3 is an integer of 1; each of R1, R2, R3, R4, R5, and R6 is independently a hydrogen atom; A1 is imidazole; A2 is imidazole or imidazole substituted with an alkyl group; W is a phenyl group or naphthyl group; X is CH2; D is a group represented by -Q-Y—B, wherein Q is NR12 and R12 is a hydrogen atom or an alkyl group; Y is (CH2)m3 and m3 is an integer of 2 to 4; and B is N(R25R26), wherein each of R25 and R26 are independently a hydrogen atom, a C1–C6 alkyl group or a C3–C6 cycloalkyl group.
公开/授权文献
- US20050165063A1 Amine compounds and use thereof 公开/授权日:2005-07-28