Invention Grant
- Patent Title: Water-soluble etoposide analogs and methods of use thereof
- Patent Title (中): 水溶性依托泊苷类似物及其使用方法
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Application No.: US10712663Application Date: 2003-11-13
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Publication No.: US07176236B2Publication Date: 2007-02-13
- Inventor: Kuo-Hsiung Lee , Zhiyan Xiao , Kenneth F. Bastow
- Applicant: Kuo-Hsiung Lee , Zhiyan Xiao , Kenneth F. Bastow
- Applicant Address: US NC Chapel Hill
- Assignee: University of North Carolina at Chapel Hill
- Current Assignee: University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Myers Bigel Sibley & Sajovec, P.A.
- Main IPC: A61K31/335
- IPC: A61K31/335 ; C07D407/00 ; C07D307/77
Abstract:
Etoposide analogs with improved water-solubility such as 4′-O-Demethyl-4′-(N′,N′-dimethyl-glycyl)-4β-(4″-nitroanilino)-4-desoxy-podophyllotoxin (8) and 4′-O-Demethyl-4′-(N′,N′-dimethyl-glycyl)-4β-(4″-fluoroanilino)-4-desoxy-podophyllotoxin (9) are described, along with pharmaceutical formulations containing the same, methods of use thereof, and intermediates and methods of making the same.
Public/Granted literature
- US20040106676A1 Water-soluble etoposide analogs and methods of use thereof Public/Granted day:2004-06-03
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