An avoidance method for co-channel interference in a wireless network. The first step of the method is to evaluate an interference measure on each subcarrier. Based on the interference measure of each subcarrier, a peak-to-average measure ratio of interference within the received symbol is then obtained. If the peak-to-average measure ratio of interference is greater than a predetermined threshold, a most interfered subcarrier at which the maximal interference measure occurs is detected. Accordingly, a downgrading factor is set for the most interfered subcarrier.