发明授权
- 专利标题： VLA-4 inhibitor compounds
- 专利标题（中）： VLA-4抑制剂化合物
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申请号： US10787905申请日： 2004-02-26
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公开(公告)号： US07179819B2公开(公告)日： 2007-02-20
- 发明人: John J. Baldwin , Edward McDonald , Kevin Joseph Moriarty , Christopher Ronald Sarko , Nobuo Machinaga , Atsushi Nakayama , Jun Chiba , Iimura Shin , Yoshiyuki Yoneda
- 申请人： John J. Baldwin , Edward McDonald , Kevin Joseph Moriarty , Christopher Ronald Sarko , Nobuo Machinaga , Atsushi Nakayama , Jun Chiba , Iimura Shin , Yoshiyuki Yoneda
- 申请人地址： JP Tokyo US NJ Cranbury
- 专利权人： Daiichi Pharmaceutical Co., Ltd.,Pharmacopeia Drug Discovery, Inc.
- 当前专利权人： Daiichi Pharmaceutical Co., Ltd.,Pharmacopeia Drug Discovery, Inc.
- 当前专利权人地址： JP Tokyo US NJ Cranbury
- 代理机构： Heslin Rothenberg Farley & Mesiti P.C.
- 主分类号： C07D277/04
- IPC分类号： C07D277/04 ; A61K31/425 ; C07D207/12
摘要：
Compounds that selectively inhibit the binding of ligands to α4β1 integrin (VLA-4) and methods for their preparation are disclosed. In one embodiment, compounds of the invention are represented by Formula I: As selective inhibitors of VLA-4 mediated cell adhesion, compounds of the present invention are useful in the treatment of conditions associated with such adhesion, including, but not limited to, such conditions as inflammatory and autoimmune responses, diabetes, asthma, psoriasis, inflammatory bowel disease, transplantation rejection, and tumor metastasis. Also disclosed are methods of inhibiting VLA-4 mediated cell adhesion and methods of treating conditions associated with LA-4 mediated cell adhesion.
公开/授权文献
- US20040229858A1 VLA-4 inhibitor compounds 公开/授权日：2004-11-18