A printing method and printing apparatus can print a high-quality image free from any visual graininess by reducing density unevenness and color unevenness. In printing by discharging ink from a printhead onto a printing medium, the printing apparatus executes either one of (A) a first printing operation mode in which one dot layout pattern is assigned to a plurality of pixels at the same gradation level and printing is done on the basis of the assigned dot layout pattern, or (B) a second printing operation mode in which plural types of dot layout patterns are assigned to a plurality of pixels at the same gradation level and printing is done on the basis of the assigned dot layout patterns.