发明授权
US07198946B2 Screening for agents effective in decreasing abnormal macrophages associated with amyotrophic lateral sclerosis
失效
筛选有效减少与肌萎缩性侧索硬化有关的异常巨噬细胞的药剂
- 专利标题： Screening for agents effective in decreasing abnormal macrophages associated with amyotrophic lateral sclerosis
- 专利标题（中）： 筛选有效减少与肌萎缩性侧索硬化有关的异常巨噬细胞的药剂
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申请号： US10299946申请日： 2002-11-18
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公开(公告)号： US07198946B2公开(公告)日： 2007-04-03
- 发明人: Laurence J. Marton , Tennore M. Ramesh , Sean Scott , Michael McGrath
- 申请人： Laurence J. Marton , Tennore M. Ramesh , Sean Scott , Michael McGrath
- 申请人地址： US CA San Francisco
- 专利权人： Pathologica, LLC
- 当前专利权人： Pathologica, LLC
- 当前专利权人地址： US CA San Francisco
- 代理机构： Cooley Godward Kronish LLP
- 主分类号： C12N5/08
- IPC分类号： C12N5/08 ; G01N33/53 ; C12Q1/02
摘要：
The invention provides methods of monitoring amyotrophic lateral sclerosis (ALS) disease development or progression and monitoring an ALS therapy by determining the level of HLA-DR expression by CD14+ monocytes and/or the percentage of CD16+ cells in the population of CD14+ cells and/or the number of CD14+/CD16+ cells in peripheral blood of an individual with ALS. The invention is also directed to methods for decreasing the number of circulating CD14+ monocytes and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual with ALS. The invention is also directed to methods of screening for agents which decrease the population of CD14+ monocytes with elevated HLA-DR expression and/or the population of CD14+/CD16+ cells and/or the number of CD14+/CD16+ cells in an individual with ALS.
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