发明授权
- 专利标题： Spiro-cyclic compounds useful as anti-inflammatory agents
- 专利标题（中）： 用作抗炎剂的螺环化合物
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申请号： US10957255申请日： 2004-10-01
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公开(公告)号： US07199125B2公开(公告)日： 2007-04-03
- 发明人: T. G. Murali Dhar , Edwin Iwanowicz , Michele Launay , Dominique Potin , Magali Jeannine Blandine Maillet , Eric Nicolai
- 申请人： T. G. Murali Dhar , Edwin Iwanowicz , Michele Launay , Dominique Potin , Magali Jeannine Blandine Maillet , Eric Nicolai
- 申请人地址： US NJ Princeton FR Rueil-Malmaison, Cedex
- 专利权人： Bristol-Myers Squibb Company,Cerep SA
- 当前专利权人： Bristol-Myers Squibb Company,Cerep SA
- 当前专利权人地址： US NJ Princeton FR Rueil-Malmaison, Cedex
- 代理商 Laurelee A. Duncan
- 主分类号： C07D497/20
- IPC分类号： C07D497/20 ; C07D498/20 ; A61K31/424 ; A61K31/429 ; A61K31/506
摘要：
The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K and L are independently, O or S; Q is —C(═O)— or optionally substituted C1-6alkylene; Ar is optionally-substituted aryl or heteroaryl; J1, J2, J3 and Y are selected so that ring A is a five-to-six membered optionally-substituted cycloalkenyl or heterocyclo ring having 0 to 2 nitrogen heteroatoms; R1 is N or C(R9); and R2, and R3, are as defined in the specification.