发明授权
- 专利标题: Process for preparing nitrooxyderivatives of naproxen
- 专利标题(中): 制备萘普生硝基氧化酶的方法
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申请号: US10523722申请日: 2003-08-06
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公开(公告)号: US07199258B2公开(公告)日: 2007-04-03
- 发明人: Piero Del Soldato , Giancarlo Santus , Francesca Benedini
- 申请人: Piero Del Soldato , Giancarlo Santus , Francesca Benedini
- 申请人地址: FR Sophia Antipolis - Valbonne
- 专利权人: Nicox S.A.
- 当前专利权人: Nicox S.A.
- 当前专利权人地址: FR Sophia Antipolis - Valbonne
- 代理机构: Arent Fox LLP
- 优先权: ITMI02A1861 20020829
- 国际申请: PCT/EP03/08698 WO 20030806
- 国际公布: WO2004/020384 WO 20040311
- 主分类号: C07C203/04
- IPC分类号: C07C203/04
摘要:
The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of naproxen or bromonaproxen and R1–R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R—COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1–R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.
公开/授权文献
- US20060173005A1 Process for preparing nitrooxyderivative of naproxen 公开/授权日:2006-08-03
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