发明授权
US07202268B2 Derivatives of indole-3-carboxamide, preparation method thereof and application of same in therapeutics
失效
吲哚-3-甲酰胺的衍生物，其制备方法及其在治疗中的应用
- 专利标题： Derivatives of indole-3-carboxamide, preparation method thereof and application of same in therapeutics
- 专利标题（中）： 吲哚-3-甲酰胺的衍生物，其制备方法及其在治疗中的应用
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申请号： US11138843申请日： 2005-05-26
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公开(公告)号： US07202268B2公开(公告)日： 2007-04-10
- 发明人: Francis Barth , Mireille Rinaldi-Carmona , Claude Vernhet
- 申请人： Francis Barth , Mireille Rinaldi-Carmona , Claude Vernhet
- 申请人地址： FR Paris
- 专利权人： Sanofi-aventis
- 当前专利权人： Sanofi-aventis
- 当前专利权人地址： FR Paris
- 代理商 Balaram Gupta
- 优先权： FR0215086 20021129
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/405 ; C07D209/42 ; C07D209/12 ; C07D209/18
摘要：
The invention relates to derivatives of indole-3-carboxamide having general formula (I): wherein: R1 represents a C3–C10 alkyl, a C5–C10 carbocyclic radical that is unsubstituted or substituted one or more times with a methyl group; R2 represents a hydrogen atom or a (C1–C4)alkyl group; R3 represents a halogen atom or a (C1–C4)alkyl group; R4 represents a hydrogen or halogen atom or a (C1–C4)alkyl group; R5 represents a (C1–C4)alkyl group or a trifluoromethyl; X represents a sulfur atom, an —NHSO2— group or an —SO2— group; and n is equal to 2 or 3. The invention also relates to a method of preparing the aforementioned derivatives and to the application of same in therapeutics.
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