发明授权
- 专利标题: Benzamidine derivatives having anti-inflammatory and immunosuppressive activity
- 专利标题(中): 具有抗炎和免疫抑制活性的苯甲脒衍生物
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申请号: US10467624申请日: 2002-02-06
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公开(公告)号: US07202277B2公开(公告)日: 2007-04-10
- 发明人: Francesco Makovec , Simona Zanzola , Roberto Artusi , Lucio Claudio Rovati
- 申请人: Francesco Makovec , Simona Zanzola , Roberto Artusi , Lucio Claudio Rovati
- 申请人地址: IT Milan
- 专利权人: Rotta Research Laboratorium S.p.A.
- 当前专利权人: Rotta Research Laboratorium S.p.A.
- 当前专利权人地址: IT Milan
- 代理机构: Sughrue Mion, PLLC
- 优先权: ITTO01A0110 20010208
- 国际申请: PCT/EP02/01201 WO 20020206
- 国际公布: WO02/070468 WO 20020912
- 主分类号: A61K31/17
- IPC分类号: A61K31/17
摘要:
Compounds which can be represented by the general formula (I) indicated below: and in which: A is selected independently from the carboxamide group, the thiocarboxamide group, and the carbonyl group, R1 is selected from an alkyl group having from 1 to 3 carbon atoms and the amino group, unsubstituted or substituted with the nitro group or the methyl group, R2 is selected independently from hydrogen, an alkyl group having from 1 to 4 carbon atoms, the methoxy, ethoxy, propoxy group, a mono-, bi- or tricyclic cycloalkane residue having from 5 to 12 carbon atoms, the adamantyl group, an aryl, naphthyl or heterocyclic group, unsubstituted or substituted with methyl, methoxy, hydroxy, amino or halogen groups, R3 and R4 are selected independently from hydrogen and an alkyl group having from 1 to 3 carbon atoms, R5 represents one or two substituents independently selected from hydrogen and the methyl, methoxyl and hydroxyl groups, n is a whole number from 0 to 6, and the amidine group is in the para or meta position relative to the “-A-NH—” group.
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