发明授权
- 专利标题: Attenuation of cytomegalovirus virulence
- 专利标题(中): 巨细胞病毒毒力的衰减
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申请号: US09724935申请日: 2000-11-28
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公开(公告)号: US07204990B1公开(公告)日: 2007-04-17
- 发明人: George Kemble , Gregory M. Duke , Richard Spaete
- 申请人: George Kemble , Gregory M. Duke , Richard Spaete
- 申请人地址: US CA Mountain View
- 专利权人: MedImmune Vaccines, Inc.
- 当前专利权人: MedImmune Vaccines, Inc.
- 当前专利权人地址: US CA Mountain View
- 代理机构: MedImmune Vaccines, Inc.
- 代理商 Lisa Kreppel; Janet Martineau
- 主分类号: A61K39/245
- IPC分类号: A61K39/245 ; A61K39/12 ; C12Q1/70
摘要:
A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
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