发明授权
US07205304B2 Sulfonyl-Derivatives as novel inhibitors of histone deacetylase
有权
磺酰衍生物作为组蛋白脱乙酰酶的新型抑制剂
- 专利标题： Sulfonyl-Derivatives as novel inhibitors of histone deacetylase
- 专利标题（中）： 磺酰衍生物作为组蛋白脱乙酰酶的新型抑制剂
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申请号： US10507708申请日： 2003-03-11
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公开(公告)号： US07205304B2公开(公告)日： 2007-04-17
- 发明人: Kristof Van Emelen , Janine Arts , Leo Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noëlle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviane Van heusden
- 申请人： Kristof Van Emelen , Janine Arts , Leo Jacobus Jozef Backx , Hans Louis Jos De Winter , Sven Franciscus Anna Van Brandt , Marc Gustaaf Celine Verdonck , Lieven Meerpoel , Isabelle Noëlle Constance Pilatte , Virginie Sophie Poncelet , Alexey Borisovich Dyatkin , Jimmy Arnold Viviane Van heusden
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人地址： BE Beerse
- 国际申请： PCT/EP03/02516 WO 20030311
- 国际公布： WO03/076422 WO 20030918
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; C07D403/04 ; C07D239/69
摘要：
This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine