发明授权
- 专利标题： Peroxisome proliferator activated receptor alpha agonists
- 专利标题（中）： 过氧化物酶体增殖物激活受体α激动剂
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申请号： US10495204申请日： 2002-11-13
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公开(公告)号： US07205321B2公开(公告)日： 2007-04-17
- 发明人: Richard Duane Johnston , Nathan Bryan Mantlo , Richard Craig Thompson
- 申请人： Richard Duane Johnston , Nathan Bryan Mantlo , Richard Craig Thompson
- 申请人地址： US IN Indianapolis
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： US IN Indianapolis
- 代理商 MaCharri Vorndran-Jones
- 国际申请： PCT/US02/33632 WO 20021113
- 国际公布： WO03/043997 WO 20030530
- 主分类号： A61K31/4245
- IPC分类号： A61K31/4245 ; C07D271/10
摘要：
The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is selected from the group consisting of hydrogen, substituted or unsubstituted group selected from C1–C8 alkyl, aryl-C0-4-alkyl, heteroaryl-C0-4-alkyl, and C3–C6 cycloalkylaryl-C0-2-alkyl; W is O or S; X is an optionally substituted C1–C5 alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S; Y is C, O, S, NH or a single bond; E is C(R3)(R4)A or A
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