发明授权
- 专利标题： Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences
- 专利标题（中）： 从克隆的核苷酸序列产生减毒副流感病毒疫苗
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申请号： US09083793申请日： 1998-05-22
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公开(公告)号： US07208161B1公开(公告)日： 2007-04-24
- 发明人: Brian R. Murphy , Peter L. Collins , Anna P. Durbin , Mario H. Skiadopoulos , Tao Tao
- 申请人： Brian R. Murphy , Peter L. Collins , Anna P. Durbin , Mario H. Skiadopoulos , Tao Tao
- 申请人地址： US DC Washington
- 专利权人： The United States of America, represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 主分类号： A61K39/155
- IPC分类号： A61K39/155 ; C12N7/00
摘要：
Isolated polynucleotide molecules provide recombinant PIV genomes and antigenomes for production of recombinant PIV vaccines. The recombinant genome or antigenome can be expressed with a nucleoprotein (N), phosphoprotein (P), and a large (L) polymerase protein to produce isolated infectious PIV particles. The recombinant PIV genome and antigenome can be modified to produce desired changes, for example to incorporate attenuating mutations from biologically derived PIV mutants or to create chimeric PIV clones, to generate attenuated, immunogenic viruses for vaccine use.
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