- 专利标题： Tripeptide prodrug compounds
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申请号： US10311519申请日： 2001-06-11
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公开(公告)号： US07214663B2公开(公告)日： 2007-05-08
- 发明人: Christopher R. Bebbington , Vincent Dubois , Sanjeev Gangwar , Thomas J. Lobl , Matthew H. Nieder , Lesley B. Pickford , Andre Trouet , Geoffrey T. Yarranton
- 申请人： Christopher R. Bebbington , Vincent Dubois , Sanjeev Gangwar , Thomas J. Lobl , Matthew H. Nieder , Lesley B. Pickford , Andre Trouet , Geoffrey T. Yarranton
- 申请人地址： US NJ Princeton
- 专利权人： Medarex, Inc.
- 当前专利权人： Medarex, Inc.
- 当前专利权人地址： US NJ Princeton
- 代理机构： Lahive & Cockfield, LLP
- 代理商 Jane E. Remillard, Esq.; Cynthia M. Soroos, Esq.
- 国际申请： PCT/US01/40925 WO 20010611
- 国际公布： WO02/00263 WO 20020103
- 主分类号： C07K5/083
- IPC分类号： C07K5/083 ; A61K38/06
摘要：
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopeptidase. Also disclosed are methods of making and using the prodrug compounds.
公开/授权文献
- US20030181359A1 Tripeptide prodrug compounds 公开/授权日：2003-09-25
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