发明授权
- 专利标题: Phenalene derivatives
- 专利标题(中): 萘衍生物
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申请号: US10852735申请日: 2004-05-24
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公开(公告)号: US07217717B2公开(公告)日: 2007-05-15
- 发明人: Kin-Chun Luk , Zhuming Zhang
- 申请人: Kin-Chun Luk , Zhuming Zhang
- 申请人地址: US NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni
- 主分类号: A61K31/505
- IPC分类号: A61K31/505 ; A61K31/519 ; C07D471/12 ; C07D487/12
摘要:
Novel 1,3,4-triaza-phenalene and 1,3,4,6-tetraazaphenalene derivatives are disclosed. These compounds inhibit epidermal growth factor receptor (“EGFR”) tyrosine kinase. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful, inter alia, in the treatment or control of cancer, in particular solid tumors. This invention also relates to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors.
公开/授权文献
- US20040254205A1 Phenalene derivatives 公开/授权日:2004-12-16