The invention is an optical reader having a plurality of image sensors. Each image sensor of a plural image sensor optical reader can be disposed on an imaging module that can include a light source. In one embodiment, a frame of image data captured via actuation of an image sensor of a first imaging module and actuation of illumination of a second imaging module is subjected to decoding. The various modules of a multiple imaging module reader can be adapted to have different best focus positions so that a field depth of the reader is improved.