发明授权
US07220399B2 Alpha or beta emitters attached to fragments in radioimmunotherapy
有权
在放射免疫治疗中附着于片段的α或β发射体
- 专利标题： Alpha or beta emitters attached to fragments in radioimmunotherapy
- 专利标题（中）： 在放射免疫治疗中附着于片段的α或β发射体
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申请号： US10724397申请日： 2003-12-01
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公开(公告)号： US07220399B2公开(公告)日： 2007-05-22
- 发明人: David M. Goldenberg , Thomas M. Behr
- 申请人： David M. Goldenberg , Thomas M. Behr
- 申请人地址： US NJ Belleville
- 专利权人： Center For Molecular Medicine and Immunology
- 当前专利权人： Center For Molecular Medicine and Immunology
- 当前专利权人地址： US NJ Belleville
- 代理机构： Faegre & Benson LLP
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; A61K9/16 ; A61K9/47
摘要：
The present invention relates to radioimmunoconjugates useful in targeted radioimmunotherapy and methods of treating a patient using radioimmunoconjugates. The radioimmunoconjugates of the present invention comprise an alpha- or beta-emitting radioisotope and a binding site linked to or on an antigen-binding fragment of an antibody which specifically binds to a tumor-associated antigen. The methods of treating a patient can include administering one or more clearing agents to the patient in conjunction with the radioimmunoconjugate of the present invention, as well as subsequently grafting bone-marrow or autologous stem-cells to the patient.
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