发明授权
US07223834B2 Assays and peptide substrate for determining aggrecan degrading metallo protease activity
失效
用于测定聚集蛋白聚糖降解金属蛋白酶活性的测定和肽底物
- 专利标题： Assays and peptide substrate for determining aggrecan degrading metallo protease activity
- 专利标题（中）： 用于测定聚集蛋白聚糖降解金属蛋白酶活性的测定和肽底物
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申请号： US09975813申请日： 2001-10-12
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公开(公告)号： US07223834B2公开(公告)日： 2007-05-29
- 发明人: Jeffrey A. Miller , Elizabeth C. Arner , Robert A. Copeland , Gary L. Davis , Ruiqin Liu , Michael A. Pratta , Micky D. Tortorella
- 申请人： Jeffrey A. Miller , Elizabeth C. Arner , Robert A. Copeland , Gary L. Davis , Ruiqin Liu , Michael A. Pratta , Micky D. Tortorella
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Brian C. Carey
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/17 ; C12N9/00 ; C12N9/14
摘要：
This invention is directed to assays to determine the presence or absence of proteins that exhibit aggrecanase or ADMP activity. This invention also relates to peptides that acts as a substrates for ADMPs, their use in various assays to determine the presence or absence of ADMP activity, and their use as inhibitors of ADMP activity.
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