A portable patient support includes a platform having a rigid platform received in an interior of an end cap. Elongated rails attached to side walls of the end cap receive accessories, such as stirrups for elevating a patient's legs during insertion of brachytherapy needles for treating prostate cancer and a leg support table for comfortable support of a patient's legs during transport. The portable patient support also has a transfer device including an inflatable mattress having micro-fenestrations in a bottom sheet or a semi-rigid sliding member located beneath the platform. The platform is preferably secured to the transfer device, using straps or by receipt of the platform in built-in pocket. Alternatively, the support may include a fenestrated lower tray attached to the platform by expandable connectors to contain the transfer device. A method of preparing a patient for prostate brachytherapy using the portable patient support is described.