发明授权
- 专利标题： Amorphous substance of tricyclic triazolobenzazepine derivative
- 专利标题（中）： 三环三氮苯并氮杂衍生物的无定形物质
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申请号： US10500071申请日： 2002-12-25
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公开(公告)号： US07229985B2公开(公告)日： 2007-06-12
- 发明人: Toyoaki Ishikura , Takayuki Ishizawa , Kenji Suemune , Mayumi Ishiwata , Chikako Udagawa
- 申请人： Toyoaki Ishikura , Takayuki Ishizawa , Kenji Suemune , Mayumi Ishiwata , Chikako Udagawa
- 申请人地址： JP Tokyo-to
- 专利权人： Meiji Seika Kaisha, Ltd.
- 当前专利权人： Meiji Seika Kaisha, Ltd.
- 当前专利权人地址： JP Tokyo-to
- 代理机构： Heller Ehrman LLP
- 优先权： JP2001-393016 20011226
- 国际申请： PCT/JP02/13558 WO 20021225
- 国际公布： WO03/055886 WO 20030710
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/55 ; A61K9/14 ; A61K47/38
摘要：
Disclosed are 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H), 10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine, which has been rendered amorphous and possesses improved absorption and dissoluvability, and a pharmaceutical composition comprising the same. Also disclosed are processes for producing 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H), 10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine, which has been rendered amorphous, and a pharmaceutical composition comprising the same.