发明授权
US07238694B2 Rifamycin imino derivatives effective against drug-resistant microbes
有权
对抗耐药性微生物有效的利福霉素亚氨基衍生物
- 专利标题： Rifamycin imino derivatives effective against drug-resistant microbes
- 专利标题（中）： 对抗耐药性微生物有效的利福霉素亚氨基衍生物
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申请号： US11034279申请日： 2005-01-12
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公开(公告)号： US07238694B2公开(公告)日： 2007-07-03
- 发明人: Charles Z. Ding , Yafei Jin , Jamie C. Longgood , Zhenkun Ma , Jing Li , In Ho Kim , Keith P. Minor , Susan Harran
- 申请人： Charles Z. Ding , Yafei Jin , Jamie C. Longgood , Zhenkun Ma , Jing Li , In Ho Kim , Keith P. Minor , Susan Harran
- 申请人地址： US TX Dallas
- 专利权人： Cumbre Pharmaceuticals, Inc.
- 当前专利权人： Cumbre Pharmaceuticals, Inc.
- 当前专利权人地址： US TX Dallas
- 代理机构： Jackson Walker L.L.P.
- 主分类号： C07D498/08
- IPC分类号： C07D498/08 ; C07D519/00 ; A61K31/4709 ; A61K31/496 ; A61P31/04
摘要：
The present invention relates to rifamycin 3-iminomethylenyl (—CH═N—) derivatives having antimicrobial activities, including activities against drug-resistant microorganisms. The claimed rifamycin derivative has a rifamycin moiety covalently linked to a linker through an iminomethylenyl (—CH═N—) group at the C-3 carbon of the rifamycin moiety and the linker is, in turn, covalently linked to a quinolone structure or its pharmacophore within the DNA gyrase and topoisomerase IV inhibitor family. The inventive rifamycins are novel and exhibit activity against both rifampin and ciprofloxacin-resistant microorganisms.
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