The multiple compartment pill dispenser has a rotatable cap mechanism having two holes associated with the cap which are displaceable to be aligned with each of the compartments of the dispenser. There are two standard sized holes, one for small pills and one for large pills. The dial cap mechanism is used to rotate one of the two holes into alignment with a particular pill compartment and allow a pill to be dispensed therefrom. As a closure device, an alignment plate is rotatably mounted in the cap mechanism. The alignment plate also includes two different sized holes, identical in diameter, respectively, to the two holes in the cap mechanism.