发明授权
US07244762B2 Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted sulfamates
有权
抗肿瘤D-同型异构-1,3,5（10） - 三烯-3-基2-取代的亚磺酸盐
- 专利标题： Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted sulfamates
- 专利标题（中）： 抗肿瘤D-同型异构-1,3,5（10） - 三烯-3-基2-取代的亚磺酸盐
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申请号： US10546230申请日： 2004-02-19
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公开(公告)号： US07244762B2公开(公告)日： 2007-07-17
- 发明人: Alexander Hillisch , Olaf Peters , Christian Gege , Gerhard Siemeister , Eberhard Unger , Bernd Menzenbach
- 申请人： Alexander Hillisch , Olaf Peters , Christian Gege , Gerhard Siemeister , Eberhard Unger , Bernd Menzenbach
- 申请人地址： GB Berkshire
- 专利权人： Sterix Limited
- 当前专利权人： Sterix Limited
- 当前专利权人地址： GB Berkshire
- 代理机构： Millen, White, Zelano & Branigan, P.C.
- 优先权： DE10307103 20030219
- 国际申请： PCT/EP2004/001629 WO 20040219
- 国际公布： WO2004/074309 WO 20040902
- 主分类号： C07J31/00
- IPC分类号： C07J31/00 ; C07J41/00 ; C07J63/00 ; A61K31/565 ; A61P35/00
摘要：
This invention relates to 2-substituted D-homo-estra-1,3,5(10)-trien-3-yl sulfamates of general formula I (I), in which R3 means a C1-C5-alkyl or C1-C5-alkyloxy group as well as their use for the production of a pharmaceutical agent for treating tumor diseases, which can be influenced positively by the inhibition of tubulin polymerization. The compounds according to the invention are distinguished by a D-homosubstitution. They have a special action with respect to tubulin polymerization inhibition and can be used, for example, for treating prostate cancer
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