发明授权
US07250408B2 Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility
失效
糖皮质激素受体拮抗剂用于预防和治疗糖皮质激素介导的性腺机能减退症，性功能障碍和/或不育症
- 专利标题： Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility
- 专利标题（中）： 糖皮质激素受体拮抗剂用于预防和治疗糖皮质激素介导的性腺机能减退症，性功能障碍和/或不育症
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申请号： US10735487申请日： 2003-12-12
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公开(公告)号： US07250408B2公开(公告)日： 2007-07-31
- 发明人: Ulrich Bothe , Gerd Schubert , Guenter Kaufmann , Lothar Sobek , Vladimir Patchev , Alexander Hillisch
- 申请人： Ulrich Bothe , Gerd Schubert , Guenter Kaufmann , Lothar Sobek , Vladimir Patchev , Alexander Hillisch
- 申请人地址： DE Berlin
- 专利权人： Bayer Schering Pharma AG
- 当前专利权人： Bayer Schering Pharma AG
- 当前专利权人地址： DE Berlin
- 代理商 Michael J. Striker
- 优先权： DE10259004 20021216
- 主分类号： A61K31/56
- IPC分类号： A61K31/56 ; C07J1/00
摘要：
The novel glucocorticoid receptor antagonists are 11β-substituted steroid compounds of formula (I): wherein R1 denotes a methyl group, a methoxy group, or an ethoxy group; wherein R2 denotes a tert.-butyl group, a 1-hydroxy-1-methylethyl group, a 1-methoxy-1-methylethyl group, an ethyl isocrotonate group, or a substituted phenyl group. The method of treating an individual suffering from glucocorticoid-mediated hypogonadism, sexual dysfunctions, and/or infertility includes administering a daily dosage consisting of an effective amount of one of these 11β-substituted steroid compounds.
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