发明授权
- 专利标题： N-heterocyclic inhibitors of TNF-α expression
- 专利标题（中）： TNF-α表达的N-杂环抑制剂
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申请号： US11485075申请日： 2006-07-12
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公开(公告)号： US07253174B2公开(公告)日： 2007-08-07
- 发明人: Gulzar Ahmed , Axel Metzger , Ian Henderson , David J. Diller , Jun Wen , Stephen T. Wrobleski , Katerina Leftheris , Chunjian Liu
- 申请人： Gulzar Ahmed , Axel Metzger , Ian Henderson , David J. Diller , Jun Wen , Stephen T. Wrobleski , Katerina Leftheris , Chunjian Liu
- 申请人地址： US NJ Princeton US NJ Cranbury
- 专利权人： Bristol-Myers Squibb Company,Pharmacopeia, Inc.
- 当前专利权人： Bristol-Myers Squibb Company,Pharmacopeia, Inc.
- 当前专利权人地址： US NJ Princeton US NJ Cranbury
- 代理商 Maureen P. O'Brien; Joseph C. Wang
- 主分类号： C07D239/48
- IPC分类号： C07D239/48 ; A61K31/505
摘要：
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
公开/授权文献
- US20060276488A1 N-heterocyclic inhibitors of TNF-alpha expression 公开/授权日：2006-12-07