发明授权
- 专利标题: Guanidino derivatives as inhibitors of cell adhesion
- 专利标题(中): 胍基衍生物作为细胞粘附抑制剂
-
申请号: US10343173申请日: 2001-07-23
-
公开(公告)号: US07259159B2公开(公告)日: 2007-08-21
- 发明人: Anuschirwan Peyman , David Will , Thomas R Gadek , Robert McDowell , Jean Francois Gourvest , Jean-Marie Ruxer , Jochen Knolle
- 申请人: Anuschirwan Peyman , David Will , Thomas R Gadek , Robert McDowell , Jean Francois Gourvest , Jean-Marie Ruxer , Jochen Knolle
- 申请人地址: DE Frankfurt am Main US CA South San Francisco
- 专利权人: Sanofi-Aventis Deutschland GmbH,Genentech Inc.
- 当前专利权人: Sanofi-Aventis Deutschland GmbH,Genentech Inc.
- 当前专利权人地址: DE Frankfurt am Main US CA South San Francisco
- 代理商 James W. Bolcsak
- 优先权: EP00116385 20000728
- 国际申请: PCT/EP01/08485 WO 20010723
- 国际公布: WO02/10168 WO 20020207
- 主分类号: C07D471/04
- IPC分类号: C07D471/04 ; C07D487/04 ; C07D473/16 ; C07D473/24 ; C07D473/28 ; C07D473/32 ; C07D473/34 ; C07D473/36 ; C07D473/40 ; A61K31/437 ; A61K31/519
摘要:
The present invention relates to acylguanidino derivatives of formula (I), in which R1, R2, R3, A, B, X, Y and n have the meanings indicated in claim 1, their physiologically tolerable salts and their prodrugs. The compounds of the formula (I) are valuable pharmaceutically active compounds. They are vitronectin receptor antagonists and inhibitors of cell adhesion and bone resorption by osteoclasts. This renders them suitable, for example, for the therapy and prophylaxis of illness which are based on the interaction between vitronectin receptors and their ligands in cell-cell or cell-matrix interaction processes or which can be prevented, alleviated or cured by influencing such interactions. For example, they can be applied for treating and preventing osteoporosis, or for inhibiting undesired angiogenesis or proliferation of cells of the vascular smooth muscles. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as pharmaceutical active ingredients, and pharmaceutical compositions comprising them
公开/授权文献
信息查询