发明授权
US07268153B2 N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
失效
N-(2-苄基)-2-苯基丁酰胺作为雄激素受体调节剂
- 专利标题: N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
- 专利标题(中): N-(2-苄基)-2-苯基丁酰胺作为雄激素受体调节剂
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申请号: US11145490申请日: 2005-06-03
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公开(公告)号: US07268153B2公开(公告)日: 2007-09-11
- 发明人: Barbara Hanney , Yuntae Kim , Michael R. Krout , Robert S. Meissner , Helen J. Mitchell , Jeffrey Musselman , James J. Perkins , Jiabing Wang
- 申请人: Barbara Hanney , Yuntae Kim , Michael R. Krout , Robert S. Meissner , Helen J. Mitchell , Jeffrey Musselman , James J. Perkins , Jiabing Wang
- 申请人地址: US NJ Rahway
- 专利权人: Merck & Co., Inc.
- 当前专利权人: Merck & Co., Inc.
- 当前专利权人地址: US NJ Rahway
- 代理商 Patricia A. Shatynski; Curtis C. Panzer
- 主分类号: A61K31/165
- IPC分类号: A61K31/165
摘要:
Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.